{"id":6791,"date":"2021-03-26T00:00:00","date_gmt":"2021-03-25T23:00:00","guid":{"rendered":"https:\/\/instrid.sk\/uncategorized\/ivermektin-a-politizacia-vedy\/"},"modified":"2021-03-26T00:00:00","modified_gmt":"2021-03-25T23:00:00","slug":"ivermektin-a-politizacia-vedy","status":"publish","type":"post","link":"https:\/\/instrid.sk\/en\/archiv\/ivermektin-a-politizacia-vedy\/","title":{"rendered":"Ivermekt\u00edn a politiz\u00e1cia vedy"},"content":{"rendered":"

V poslednej dobe sledujeme ve\u013ek\u00fa polariz\u00e1ciu n\u00e1zorov<\/strong> v lek\u00e1rskej aj vedeckej obci oh\u013eadom strat\u00e9gie boja vo\u010di v\u00edrusu COVID-19.<\/p>\n

Jedni s\u00fa bezhlavo za vakcin\u00e1ciu, in\u00ed by uprednostnili profylaxiu a ambulantn\u00fa lie\u010dbu dostupn\u00fdmi a lacn\u00fdmi liekmi. \u013dudia t\u00e1paj\u00fa v mno\u017estve protichodn\u00fdch inform\u00e1cii.<\/p>\n V\u00edrus COVID-19 nesp\u00f4sobil len pand\u00e9miu, ale aj polariz\u00e1ciu n\u00e1zorov vedeckej a lek\u00e1rskej spolo\u010dnosti.\n

 <\/p>\n

\u010co stoj\u00ed za touto polariz\u00e1ciou?<\/h3>\n

V novembri 2020 vy\u0161iel v \u010dasopise BMJ \u010dl\u00e1nok s n\u00e1zvom COVID -19: Politiz\u00e1cia, \u201ekorupcia\u201c a potla\u010denie vedy. V \u010dl\u00e1nku sa objavuj\u00fa tvrdenia o politiz\u00e1cii vedy<\/strong>, ktor\u00e1 smeruje k samotn\u00e9mu potla\u010deniu vedy a obohateniu mocn\u00fdch, v \u010dl\u00e1nku sa ako d\u00f4kaz t\u00fdchto tvrden\u00ed uv\u00e1dzaj\u00fa niektor\u00e9 nekal\u00e9 praktiky odohr\u00e1vaj\u00face sa v Spojenom kr\u00e1\u013eovstve, napr. tajn\u00e9 rokovania SAGE (vedeckej poradnej skupiny pre mimoriadne situ\u00e1cie), n\u00e1sledn\u00fd \u00fanik inform\u00e1cii a v \u0148om zisten\u00e9 nedostato\u010dn\u00e9 zast\u00fapenie verejn\u00e9ho zdravotn\u00edctva.<\/p>\n

U\u017e v minulom roku sa zapo\u010dala glob\u00e1lna vakcin\u00e1cia, na trhu je viac druhov vakc\u00edn. Vakcin\u00e1cia<\/strong> v\u0161ak nie je jedin\u00e9 mo\u017en\u00e9 rie\u0161enie moment\u00e1lnej nepriaznivej epidemiologickej situ\u00e1cie.<\/p>\n

Druh\u00fdm rie\u0161en\u00edm je profylaxia a v\u010dasn\u00e1 lie\u010dba<\/strong> prostredn\u00edctvom dostupn\u00fdch liekov ako napr. Ivermekt\u00edn<\/strong>, ktor\u00fd bol u n\u00e1s schv\u00e1len\u00fd 27.1.2021 na dobu 6 mesiacov.<\/p>\n

22.3.2021 v\u0161ak EMA (Eur\u00f3pska liekov\u00e1 agent\u00fara) vyjadrila svoje odpor\u00fa\u010danie proti pou\u017eitiu lie\u010diva Ivermekt\u00edn. Uv\u00e1dza, \u017ee na lie\u010dbu COVID-19 s\u00fa nutn\u00e9 vy\u0161\u0161ie d\u00e1vky lie\u010diva ako pri in\u00fdch ochoreniach, na ktor\u00e9 sa pou\u017e\u00edva a teda nie s\u00fa jasn\u00e9 ved\u013eaj\u0161ie \u00fa\u010dinky pri zv\u00fd\u0161enej terapeutickej d\u00e1vke.<\/p>\n

S t\u00fdmto tvrden\u00edm v\u0161ak nes\u00fahlas\u00ed mno\u017estvo lek\u00e1rov, ktor\u00ed Ivermekt\u00edn pou\u017e\u00edvaj\u00fa v praxi a t\u00fato prax d\u00e1vaj\u00fa nad EBM (evidence based medicine).<\/p>\n Vakcin\u00e1cia vs. v\u010dasn\u00e1 lie\u010dba. Fotografia je ilustra\u010dn\u00e1.\n

 <\/p>\n

Fakty o Ivermekt\u00edne<\/strong><\/h3>\n

Ivermekt\u00edn bol prv\u00fdkr\u00e1t schv\u00e1len\u00fd v roku 1981 ako lie\u010divo pre zvierat\u00e1. V roku 1987 sa za\u010dal pou\u017e\u00edva\u0165 u \u013eud\u00ed na lie\u010dbu ochorenia, ktor\u00e9 sp\u00f4soboval parazit Onchocerca volvulus<\/em>\u00a0a v roku 2015 bola William C. Campbell-ovi a Satoshi \u00d3mura-ovi za jeho objavenie udelen\u00e1 Nobelova cena.<\/p>\n

Viacer\u00fdmi \u0161t\u00fadiami bolo dok\u00e1zan\u00e9, \u017ee Ivermekt\u00edn je \u0161irokospektr\u00e1lne lie\u010divo \u00fa\u010dinn\u00e9 proti niektor\u00fdm parazitom a v\u00edrusom<\/strong>. Taktie\u017e vykazuje ur\u010dit\u00e9 imunomodula\u010dn\u00e9 vlastnosti. Dok\u00e1zala sa taktie\u017e inhib\u00edcia prolifer\u00e1cie (spomalenie delenia) rakovinov\u00fdch buniek. Chemicky ide o makrocyklick\u00fd lakt\u00f3n. Ro\u010dne je u\u017e\u00edvan\u00fd 250 mili\u00f3nmi \u013eud\u00ed celosvetovo s ro\u010dn\u00fdm ziskom jednej miliardy americk\u00fdch dol\u00e1rov.<\/p>\n

V\u010faka jeho \u0161irokospektr\u00e1lnym \u00fa\u010dinkom bol Ivermekt\u00edn \u0161tudovan\u00fd in vitro (v sk\u00famavke) aj proti v\u00edrusu COVID-19. Uk\u00e1zalo sa, \u017ee Ivermekt\u00edn po\u010das 48 hod\u00edn efekt\u00edvne zabil takmer v\u0161etky vir\u00e1lne \u010dastice v sk\u00famavke. V experiment\u00e1lnych \u0161t\u00fadi\u00e1ch sa ukazuje, \u017ee lie\u010divo m\u00e1 signifikantn\u00fd \u00fa\u010dinok na za\u010diatku ochorenia SARS-CoV-2 alebo pri jeho prevencii.<\/p>\n

\u010co sa t\u00fdka toxicity, mno\u017estvo pacientov, ktor\u00ed u\u017e\u00edvali Ivermekt\u00edn, preuk\u00e1zalo, \u017ee ide o bezpe\u010dn\u00fd a dobre tolerovan\u00fd liek. Jeho ne\u017eiaduce \u00fa\u010dinky s\u00fa \u017eiadne, respekt\u00edve n\u00edzke v porovnan\u00ed so stavmi, ktor\u00e9 zapr\u00ed\u010di\u0148uj\u00fa parazity\/ v\u00edrusy. Jeho maxim\u00e1lna koncentr\u00e1cia v krvnej plazme je 4-5 hod\u00edn po po\u017eit\u00ed a pribli\u017ene po 19 hodin\u00e1ch doch\u00e1dza v pe\u010deni k zmetabolizovaniu \u00bd u\u017eitej d\u00e1vky, pri\u010dom sa vytvor\u00ed 10 metabolitov, ktor\u00e9 s\u00fa prim\u00e1rne vyl\u00fa\u010den\u00e9 stolicou, 1% je vyl\u00fa\u010den\u00e9 mo\u010dom.<\/p>\n

Ke\u010f\u017ee v\u00edrus COVID-19 nap\u00e1da bunky p\u013e\u00facnych alveol, pre efektivitu Ivermekt\u00ednu je k\u013e\u00fa\u010dov\u00e9, aby sa z krvnej plazmy dostal na miesto, kde je potrebn\u00fd – do p\u013e\u00fac. Bol vytvoren\u00fd simula\u010dn\u00fd model, ktor\u00fd uk\u00e1zal, \u017ee podan\u00edm jednej terapeutickej odpor\u00fa\u010danej d\u00e1vky Ivermekt\u00ednu sa v p\u013e\u00facach nedosiahla jeho \u017eiaduca koncentr\u00e1cia. Aj to m\u00f4\u017ee by\u0165 jeden z d\u00f4vodov, pre\u010do EMA lie\u010divo neodpor\u00fa\u010da<\/strong>. V<\/p>\n

minulom roku vy\u0161la \u0161t\u00fadia na potkanoch, v ktorej sa Ivermekt\u00edn pod\u00e1val sp\u00f4sobom nebuliz\u00e1cie, kedy sa lie\u010divo prostredn\u00edctvom neinvaz\u00edvnych met\u00f3d dost\u00e1va priamo do p\u013e\u00fac.<\/p>\n

Samozrejme, s\u00fa potrebn\u00e9 \u010fal\u0161ie \u0161t\u00fadie a testy<\/strong>, ale je ot\u00e1zne, pre\u010do sa strat\u00e9gia boja vo\u010di COVID-19 nepos\u00fava aj t\u00fdmto smerom… ale zatia\u013e \u010das be\u017e\u00ed a v st\u00e1vke je t\u00e1 najvy\u0161\u0161ia hodnota – \u013eudsk\u00fd \u017eivot.<\/p>\n S\u00fa potrebn\u00e9 \u010fal\u0161ie \u0161t\u00fadie. Fotografia je ilustra\u010dn\u00e1.\n

 <\/p>\n

 <\/p>\n

ZDROJE:<\/p>\n

(1) Heidary F., Gharebaghi R. 2020. Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. <\/span>J Antibiot, <\/span>2020 jun; 12:1-10.<\/span><\/span><\/p>\n

(2) Jermain B., Hanafin P.O., Cao Y., Lifschitz A., Lanusse C., Rao G.G. 2020. Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing. <\/span>J Pharm Sci. <\/span>2020 dec; <\/span>109(12): 3574\u20133578.<\/span><\/span><\/span><\/p>\n

(3) Juarez M., Schcolnik-Cabrera A.<\/span>, <\/span>Due\u00f1as<\/span><\/span><\/span>–<\/span><\/span><\/span>Gonzalez A. 2018. The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug. <\/span><\/span><\/span>Am J Cancer Res<\/span><\/span><\/span>. 2018; 8 (2): 317-331<\/span><\/span><\/span><\/p>\n

(4) Chaccour C., Abizanda G., Irigoyen-Barrio \u00c1., Casellas A., Aldaz A., Mart\u00ednez-Gal\u00e1n F., Hammann F., Gloria Gil A. 2020. Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats. <\/span>Sci Res. <\/span>2020; 10: 17073<\/span><\/span><\/p>\n

(5) h<\/span><\/span>ttps:\/\/www.ema.europa.eu\/en\/news\/ema-advises-against-use-ivermectin-prevention-treatment-covid-19-outside-randomised-clinical-trials<\/span><\/span><\/span><\/p>\n

(6) Covid-19: politicisation, \u201ccorruption,\u201d and suppression of science. BMJ. 2020; 371:m4425<\/span><\/span><\/span><\/p>","protected":false},"excerpt":{"rendered":"

Je Ivermekt\u00edn naozaj ne\u00fa\u010dinn\u00fd a nebezpe\u010dn\u00fd alebo je len jednou z obet\u00ed politiz\u00e1cie vedy?<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-6791","post","type-post","status-publish","format-standard","hentry","category-archiv","two-columns"],"_links":{"self":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts\/6791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/comments?post=6791"}],"version-history":[{"count":0,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts\/6791\/revisions"}],"wp:attachment":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/media?parent=6791"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/categories?post=6791"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/tags?post=6791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}