{"id":8531,"date":"2023-10-30T00:00:00","date_gmt":"2023-10-29T23:00:00","guid":{"rendered":"https:\/\/instrid.sk\/uncategorized\/alkoholizmus-nici-kazdorocne-miliony-zivotov-prevratny-sposob-liecby-by-vraj-mohol-zavislost-uplne-vyliecit\/"},"modified":"2023-10-30T00:00:00","modified_gmt":"2023-10-29T23:00:00","slug":"alkoholizmus-nici-kazdorocne-miliony-zivotov-prevratny-sposob-liecby-by-vraj-mohol-zavislost-uplne-vyliecit","status":"publish","type":"post","link":"https:\/\/instrid.sk\/en\/archiv\/alkoholizmus-nici-kazdorocne-miliony-zivotov-prevratny-sposob-liecby-by-vraj-mohol-zavislost-uplne-vyliecit\/","title":{"rendered":"Alkoholizmus ni\u010d\u00ed ka\u017edoro\u010dne mili\u00f3ny \u017eivotov: Prevratn\u00fd sp\u00f4sob lie\u010dby by mohol z\u00e1vislos\u0165 \u00faplne vylie\u010di\u0165"},"content":{"rendered":"

Alkohol je bez oh\u013eadu na vek, pohlavie, \u010di spolo\u010densk\u00e9 postavenie celosvetov\u00fdm stra\u0161iakom, a \u017eia\u013e, ve\u013emi zle s\u00fa na tom aj Slov\u00e1ci.\u00a0<\/strong><\/p>\n

Pod\u013ea Svetovej zdravotn\u00edckej organiz\u00e1cie (WHO) sa to po\u010das pand\u00e9mie Covid-19 len zhor\u0161ilo. Po\u010das pandemick\u00fdch rokov st\u00fapla spotreba alkoholu na celom svete, pri\u010dom Slovensko so spotrebou 11,1 litra ro\u010dne na obyvate\u013ea prev\u00fd\u0161ilo nielen eur\u00f3psky priemer, ale takmer dvojn\u00e1sobne aj ten svetov\u00fd.\u00a0<\/strong><\/p>\n

Alkoholizmus je probl\u00e9mom, ktor\u00fd sa net\u00fdka iba jednotlivca. Priamo s\u00favis\u00ed aj so samovra\u017edami, smrte\u013en\u00fdmi dopravn\u00fdmi nehodami \u010di so smutn\u00fdmi rodinn\u00fdmi trag\u00e9diami. \u00a0O tom, \u017ee z\u00e1visl\u00e9 na alkohole sa \u010doraz \u010dastej\u0161ie st\u00e1vaj\u00fa aj neplnolet\u00e9 deti<\/strong> sme p\u00edsali TU.<\/p>\n

\u201cNa Slovensku s\u00fa najviac konzumovan\u00fdmi psychoakt\u00edvnymi l\u00e1tkami alkohol a tabak. T\u00fdka sa to nielen dospel\u00fdch, ale aj mlad\u00fdch \u013eud\u00ed. U 15-ro\u010dn\u00fdch m\u00e1 sk\u00fasenos\u0165 s pit\u00edm alkoholu a\u017e 59 percent,“<\/em><\/strong> povedala Zuzana Kamendy z Centra pre lie\u010dbu drogov\u00fdch z\u00e1vislosti (CPLDZ) v Bratislave pre bratislavskenoviny.sk.<\/p>\n Slovensko prev\u00fd\u0161ilo nielen eur\u00f3psky priemer, ale takmer dvojn\u00e1sobne aj ten svetov\u00fd. Zdroj: unsplash.com\n

Bude z\u00e1vislos\u0165 na alkohole minulos\u0165ou?<\/h3>\n

Mo\u017eno sa p\u00fdtate, ako je mo\u017en\u00e9, \u017ee pri tom, \u010do v\u0161etko alkoholizmus sp\u00f4sobuje a ko\u013eko mili\u00f3nov \u013eud\u00ed je na \u0148om z\u00e1visl\u00fdch, sa st\u00e1le nena\u0161iel sp\u00f4sob, ako tento celosvetov\u00fd probl\u00e9m vyrie\u0161i\u0165 a vylie\u010di\u0165. Pravdou v\u0161ak je, \u017ee odborn\u00edci a vedci na tom pracuj\u00fa, a vyzer\u00e1 to tak, \u017ee ich v\u00fdskumy priniesli prv\u00e9 v\u00fdsledky.
\nSp\u00f4sob lie\u010dby, s ktor\u00fdm najnov\u0161ie vedci pri\u0161li, bol testovan\u00fd na opiciach a priniesol naozaj pozoruhodn\u00e9 v\u00fdsledky,<\/strong> informuje indy100.com\/science-tech.<\/p>\n

Ak sa rovnak\u00fd \u00faspech zopakuje aj pri \u013eudsk\u00fdch dobrovo\u013en\u00edkoch, mohlo by \u00eds\u0165 o skuto\u010dne prevratn\u00fd objav, ktor\u00fd by mohol zachr\u00e1ni\u0165 obrovsk\u00e9 mno\u017estvo \u013eud\u00ed<\/strong> a rovnako by tak priniesol obrovsk\u00fa \u00fa\u013eavu rodin\u00e1m z\u00e1visl\u00fdch.<\/p>\n

Ako prebiehal v\u00fdskum?<\/h3>\n

Z\u00e1kladom prevratn\u00e9ho v\u00fdskumu bola g\u00e9nov\u00e1 terapia, po\u010das ktorej sa sk\u00famalo p\u00f4sobenie alkoholu na mozog. Ve\u013ek\u00fd t\u00edm neurovedcov a fyziol\u00f3gov sa sna\u017eil zisti\u0165, pre\u010do maj\u00fa \u013eudia po absolvovan\u00ed be\u017enej terapie neust\u00e1lu potrebu vr\u00e1ti\u0165 sa k alkoholu.<\/strong> Pri\u0161li na to, \u017ee z ve\u013ekej \u010dasti za to m\u00f4\u017ee tzv. mezolimbick\u00e1 dopam\u00ednov\u00e1 (DA) signaliz\u00e1cia, \u010do predstavuje komunik\u00e1ciu na nervov\u00fdch dr\u00e1hach neur\u00f3nov pomocou neurotransmiteru dopam\u00ednu (v syst\u00e9me odme\u0148ovania, za \u010do zodpoved\u00e1 pr\u00e1ve prote\u00edn naz\u00fdvan\u00fd neurotrofick\u00fd faktor odvoden\u00fd od gli\u00ed (GDNF)).<\/p>\n

Ako zistili odborn\u00edci, pr\u00e1ve tieto hladiny GDNF s\u00fa u \u013eud\u00ed trpiacich alkoholizmom po\u010das obdob\u00ed abstinencie od alkoholu zn\u00ed\u017een\u00e9.\u00a0<\/strong><\/p>\n

Preto sa vedci rozhodli otestova\u0165, \u010di by pou\u017eitie g\u00e9novej terapie na dodanie tohto prote\u00ednu mohlo pom\u00f4c\u0165 posilni\u0165 k\u013e\u00fa\u010dov\u00fa dopam\u00ednergn\u00fa signaliz\u00e1ciu a zabr\u00e1ni\u0165 pacientom, aby trpeli recid\u00edvou a teda n\u00e1vratom k pitiu nadmern\u00e9ho mno\u017estva alkoholu.<\/p>\n

U \u013eud\u00ed, ktor\u00ed nie s\u00fa na alkohole z\u00e1visl\u00ed a dopraj\u00fa si ho iba pr\u00edle\u017eitostne, sp\u00f4sobuje jeho konzum\u00e1cia\u00a0uvo\u013enenie dopam\u00ednu, \u010di\u017ee pr\u00edjemn\u00e9 pocity. Pri extr\u00e9mnom u\u017e\u00edvan\u00ed alkoholu sa v\u0161ak uvo\u013e\u0148uje men\u0161ie mno\u017estvo dopam\u00ednu, a preto ak t\u00edto \u013eudia chc\u00fa za\u017ei\u0165 ten pocit euf\u00f3rie, musia toho vypi\u0165 ove\u013ea viac. \u00a0<\/strong><\/p>\n

„Tak\u017ee ke\u010f s\u00fa \u013eudia z\u00e1visl\u00ed na alkohole, v skuto\u010dnosti nec\u00edtia v\u00e4\u010d\u0161iu rados\u0165 z pitia,“<\/em><\/strong> uviedla vo vyhl\u00e1sen\u00ed Dr. Kathleen Grant, star\u0161ia spoluautorka \u0161t\u00fadie. „Zd\u00e1 sa, \u017ee pij\u00fa viac, preto\u017ee c\u00edtia potrebu udr\u017eiava\u0165 sa v opitom stave,“<\/em> vysvetlila.<\/p>\n Z\u00e1kladom v\u00fdskumu bola g\u00e9nov\u00e1 terapia, po\u010das ktorej sa sk\u00famalo p\u00f4sobenie alkoholu na mozog. Zdroj: unsplash.com\n

U op\u00edc boli v\u00fdsledky ohromuj\u00face<\/h3>\n

Pri v\u00fdskume vedci pou\u017eili osem op\u00edc – makakov,<\/strong> ktor\u00fdm sa v ka\u017edom zo \u0161tyroch 30-d\u0148ov\u00fdch\u00a0\u201einduk\u010dn\u00fdch\u201c obdob\u00ed\u00a0zv\u00fd\u0161ila koncentr\u00e1cia pod\u00e1van\u00e9ho alkoholu. Dokopy mali alkohol k dispoz\u00edcii na pol roka, ka\u017ed\u00fd de\u0148 21 hod\u00edn, kedy sa im okrem toho samozrejme pod\u00e1vala aj \u010dist\u00e1 voda. Po\u010das tejto doby sa u nich vytvorila z\u00e1vislos\u0165.<\/p>\n

Nasledovala 12-t\u00fd\u017ed\u0148ov\u00e1 abstinen\u010dn\u00e1 f\u00e1za, pri\u010dom \u0161tyri opice sa podrobili lie\u010dbe v podobe pod\u00e1vania GDNF po dobu 1 mesiaca.\u00a0V\u00fdsledky boli fantastick\u00e9! \u00a0<\/strong><\/p>\n

Opiciam op\u00e4\u0165 nastolili re\u017eim, pri ktorom mali vo\u013en\u00fd pr\u00edstup k alkoholu aj\u00a0k vode a uk\u00e1zalo sa, \u017ee opice, ktor\u00e9 sa podrobili g\u00e9novej terapii, sa konzum\u00e1cii alkoholu vyh\u00fdbali.<\/strong> Zredukovali jeho pitie do tej miery, \u017ee vedci nezaznamenali \u017eiadnu hladinu alkoholu v krvi, uviedla Dr. Grant.<\/p>\n

Na z\u00e1klade tohto najnov\u0161ieho v\u00fdskumu existuje obrovsk\u00e1 n\u00e1dej, \u017ee lieku na alkoholizmus sa svet skuto\u010dne do\u010dk\u00e1 a sn\u00e1\u010f bude dostupn\u00fd aspo\u0148 pre tie naj\u0165a\u017e\u0161ie pr\u00edpady. Je jasn\u00e9, \u017ee to e\u0161te potrv\u00e1 nejak\u00fd \u010das, k\u00fdm budeme s istotou vedie\u0165, \u010di m\u00f4\u017ee by\u0165 g\u00e9nov\u00e1 terapia zaveden\u00e1 aj u \u013eud\u00ed, ale je to d\u00f4le\u017eit\u00fd prv\u00fd krok pri rie\u0161en\u00ed tejto \u0165a\u017ekej a zni\u010duj\u00facej z\u00e1vislosti. \u00a0<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

Alkohol je bez oh\u013eadu na vek, pohlavie, \u010di spolo\u010densk\u00e9 postavenie celosvetov\u00fdm stra\u0161iakom, a \u017eia\u013e, ve\u013emi zle s\u00fa na tom aj Slov\u00e1ci.\u00a0 Pod\u013ea Svetovej zdravotn\u00edckej organiz\u00e1cie<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-8531","post","type-post","status-publish","format-standard","hentry","category-archiv","two-columns"],"_links":{"self":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts\/8531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/comments?post=8531"}],"version-history":[{"count":0,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/posts\/8531\/revisions"}],"wp:attachment":[{"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/media?parent=8531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/categories?post=8531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/instrid.sk\/en\/wp-json\/wp\/v2\/tags?post=8531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}